Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B117a20d97666797e6562415a9356dce2> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B117a20d97666797e6562415a9356dce2 NCIT_P378 "NCI" @default.
- B117a20d97666797e6562415a9356dce2 type Axiom @default.
- B117a20d97666797e6562415a9356dce2 annotatedProperty IAO_0000115 @default.
- B117a20d97666797e6562415a9356dce2 annotatedSource NCIT_C201077 @default.
- B117a20d97666797e6562415a9356dce2 annotatedTarget "A lyophilized form of recombinant human interferon (IFN) beta-1a (rhIFNb-1a), with potential protective activity. Upon dissolution of lyophilized rhIFNb-1a FP-1201 and intravenous administration, IFNb-1a upregulates the expression of and increases the levels of 5'-nucleotidase (CD73). This induces adenosine monophosphate (AMP) degradation and the production of adenosine. Adenosine acts to enhance endothelial barrier function via adenosine receptor activation and may prevent or reduce the increased vascular leakage that is due to the lack of adenosine. By increasing adenosine, rhIFNb-1a may protect the lining of blood vessels and thereby reduce inflammation. In addition, FP-1201 may prevent cytokine release syndrome (CRS) and immune effector cell associated-neurotoxicity syndrome (ICANS) toxicities in certain patients receiving CAR T-cell therapy. CD73 is abundantly expressed by normal endothelial cells." @default.