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- B11a0e406163707926ccd7cd0eacf85aa NCIT_P378 "NCI" @default.
- B11a0e406163707926ccd7cd0eacf85aa type Axiom @default.
- B11a0e406163707926ccd7cd0eacf85aa annotatedProperty IAO_0000115 @default.
- B11a0e406163707926ccd7cd0eacf85aa annotatedSource NCIT_C198220 @default.
- B11a0e406163707926ccd7cd0eacf85aa annotatedTarget "An orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase), with potential antineoplastic activity. Upon oral administration, BTK inhibitor TQB3702 targets, binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes." @default.