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- B1231b0e584cf3c77b54aaa5e858a3d88 NCIT_P378 "NCI" @default.
- B1231b0e584cf3c77b54aaa5e858a3d88 type Axiom @default.
- B1231b0e584cf3c77b54aaa5e858a3d88 annotatedProperty IAO_0000115 @default.
- B1231b0e584cf3c77b54aaa5e858a3d88 annotatedSource NCIT_C178401 @default.
- B1231b0e584cf3c77b54aaa5e858a3d88 annotatedTarget "An orally bioavailable selective inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. Upon administration, risovalisib selectively targets, binds to and inhibits wild-type PIK3CA and its mutated forms, in the PI3K/Akt (protein kinase B) /mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, this agent may be more efficacious and less toxic than pan-PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K." @default.