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- B1238827106a5d739e1514535cd0e82f1 NCIT_P378 "NCI" @default.
- B1238827106a5d739e1514535cd0e82f1 type Axiom @default.
- B1238827106a5d739e1514535cd0e82f1 annotatedProperty IAO_0000115 @default.
- B1238827106a5d739e1514535cd0e82f1 annotatedSource NCIT_C199200 @default.
- B1238827106a5d739e1514535cd0e82f1 annotatedTarget "An agonist of the stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon intravenous administration, dazostinag targets and binds to STING and activates the STING pathway in immune cells in the tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system." @default.