Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B1267f35bf717e2a6088a872b318a08f0> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B1267f35bf717e2a6088a872b318a08f0 NCIT_P378 "NCI" @default.
- B1267f35bf717e2a6088a872b318a08f0 type Axiom @default.
- B1267f35bf717e2a6088a872b318a08f0 annotatedProperty IAO_0000115 @default.
- B1267f35bf717e2a6088a872b318a08f0 annotatedSource NCIT_C37279 @default.
- B1267f35bf717e2a6088a872b318a08f0 annotatedTarget "Expressed in monocytes, lymphocytes, and placenta, human Interferon Gamma Receptor Complex (Type II Cytokine Family Receptor) is a Ser/Thr phosphorylated type I membrane protein heteromeric receptor for IFN-gamma, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. In mediating innate immune responses to viral infection, binding of IFN-gamma activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain while the integral accessory factor IFNGR2 is required for signal transduction and may interact with GAF, JAK1, and/or JAK2. (NCI)" @default.