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- B127288586e4f19d2e1ea869c76e50615 NCIT_P378 "NCI" @default.
- B127288586e4f19d2e1ea869c76e50615 type Axiom @default.
- B127288586e4f19d2e1ea869c76e50615 annotatedProperty IAO_0000115 @default.
- B127288586e4f19d2e1ea869c76e50615 annotatedSource NCIT_C1029 @default.
- B127288586e4f19d2e1ea869c76e50615 annotatedTarget "A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a metabolite that plays a critical role in protecting cells against oxidative stress, and resulting in free radical-induced apoptosis. Elevated glutathione levels are associated with tumor cell resistance to alkylating agents and platinum compounds. By depleting cells of glutathione, this agent may enhance the in vitro and in vivo cytotoxicities of various chemotherapeutic agents in drug-resistant tumors. Buthionine sulfoximine may also exhibit antiangiogenesis activity. (NCI04)" @default.