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- B1273f091a0ccc92689ea5c757f636a5c NCIT_P378 "NCI" @default.
- B1273f091a0ccc92689ea5c757f636a5c type Axiom @default.
- B1273f091a0ccc92689ea5c757f636a5c annotatedProperty IAO_0000115 @default.
- B1273f091a0ccc92689ea5c757f636a5c annotatedSource NCIT_C189085 @default.
- B1273f091a0ccc92689ea5c757f636a5c annotatedTarget "An orally bioavailable, mutant-selective, fourth-generation epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration, EGFR mutant-selective inhibitor HS-10375 targets, binds to and inhibits the activity of EGFR with C797S mutations, thereby preventing EGFR-mediated signaling. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization. HS-10375 inhibits EGFR with C797S mutations, which prevents covalent bond formation with third-generation EGFR inhibitors leading to drug resistance." @default.