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- B12cb0986a2f4c926e4adecc8188f5f8e NCIT_P378 "NCI" @default.
- B12cb0986a2f4c926e4adecc8188f5f8e type Axiom @default.
- B12cb0986a2f4c926e4adecc8188f5f8e annotatedProperty IAO_0000115 @default.
- B12cb0986a2f4c926e4adecc8188f5f8e annotatedSource NCIT_C173020 @default.
- B12cb0986a2f4c926e4adecc8188f5f8e annotatedTarget "A formulation consisting of lipid nanoparticle (LNP) encapsulating messenger RNA (mRNA) encoding the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19 activities. Upon injection, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated immune response. This may provide active immunization against SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus." @default.