Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B12e3afaf699d8bb06b5115bdef2c1bc3> ?p ?o ?g. }
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- B12e3afaf699d8bb06b5115bdef2c1bc3 hasDbXref "GOC:PARL" @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 hasDbXref "GOC:bhm" @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 hasDbXref "GOC:pad" @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 hasDbXref "PMID:21855797" @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 hasDbXref "PMID:22939624" @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 type Axiom @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 annotatedProperty IAO_0000115 @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 annotatedSource GO_1990565 @default.
- B12e3afaf699d8bb06b5115bdef2c1bc3 annotatedTarget "A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins." @default.