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- B137b06ca09a5e37c25154eebc60d486a NCIT_P378 "NCI" @default.
- B137b06ca09a5e37c25154eebc60d486a type Axiom @default.
- B137b06ca09a5e37c25154eebc60d486a annotatedProperty IAO_0000115 @default.
- B137b06ca09a5e37c25154eebc60d486a annotatedSource NCIT_C47667 @default.
- B137b06ca09a5e37c25154eebc60d486a annotatedTarget "A phenylalkylamine sympathomimetic amine with appetite depressant property. Phendimetrazine tartrate is a prodrug that is hydrolyzed to the active metabolite phenmetrazine, which competes with norepinephrine and dopamine for their presynaptic transporters, thereby blocks the reuptake of these monoamines at the neuronal junctions. As a result, this prolongs activities of dopamine and norepinephrine and leads to central nervous system (CNS) stimulation and metabolic effects, including appetite-suppression, decreased gastric acid secretion and increased blood pressure." @default.