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- B1390f2061d626cca843db7d0d0d815b4 NCIT_P378 "NCI" @default.
- B1390f2061d626cca843db7d0d0d815b4 type Axiom @default.
- B1390f2061d626cca843db7d0d0d815b4 annotatedProperty IAO_0000115 @default.
- B1390f2061d626cca843db7d0d0d815b4 annotatedSource NCIT_C28975 @default.
- B1390f2061d626cca843db7d0d0d815b4 annotatedTarget "The hydrochloride salt of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial, aquaretic and chelating activities. In bacteria, demeclocycline binds reversibly to the 30S ribosomal subunit and blocks the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex, resulting in the inhibition of protein synthesis and bacterial cell death. In mammals, this agent interferes with the action of antidiuretic hormone (ADH) at the level of the renal collecting tubule, resulting in aquaresis. In addition, demeclocycline, which like other tetracyclines chelates calcium in bone and exhibits a yellow fluorescence under ultraviolet (UV) light, may be used as a fluorescent bone-labeling agent in bone histomorphometry." @default.