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- B1399a982d0c50b0e5cdcbed4993c9d1b NCIT_P378 "KEGG" @default.
- B1399a982d0c50b0e5cdcbed4993c9d1b type Axiom @default.
- B1399a982d0c50b0e5cdcbed4993c9d1b annotatedProperty NCIT_P325 @default.
- B1399a982d0c50b0e5cdcbed4993c9d1b annotatedSource NCIT_C91811 @default.
- B1399a982d0c50b0e5cdcbed4993c9d1b annotatedTarget "Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetylcholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+, K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and H+ secretion into the stomach lumen." @default.