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- B13a566c64611d0581f632e81715fb2f6 NCIT_P378 "NCI" @default.
- B13a566c64611d0581f632e81715fb2f6 type Axiom @default.
- B13a566c64611d0581f632e81715fb2f6 annotatedProperty IAO_0000115 @default.
- B13a566c64611d0581f632e81715fb2f6 annotatedSource NCIT_C189976 @default.
- B13a566c64611d0581f632e81715fb2f6 annotatedTarget "A fixed two-agent injectable combination of the trihydrate form of meropenem, a broad-spectrum synthetic beta-lactam carbapenem antibiotic, and vaborbactam, a cyclic boronic acid beta-lactamase inhibitor, with antibacterial activity against susceptible bacteria. Upon administration of meropenem trihydrate/vaborbactam, meropenem binds to and inactivates penicillin-binding proteins (PBPs) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Vaborbactam binds to and inhibits beta-lactamase, thereby inhibiting the breakdown of meropenem, and increases the activity and therapeutic effect of meropenem." @default.