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- B143ab42b8453f71de931e12efbb051e7 NCIT_P378 "NCI" @default.
- B143ab42b8453f71de931e12efbb051e7 type Axiom @default.
- B143ab42b8453f71de931e12efbb051e7 annotatedProperty IAO_0000115 @default.
- B143ab42b8453f71de931e12efbb051e7 annotatedSource NCIT_C65983 @default.
- B143ab42b8453f71de931e12efbb051e7 annotatedTarget "The sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. Isoproterenol binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells." @default.