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- B14e940eed094b5e9ffde41b5a4398fbf NCIT_P378 "NCI" @default.
- B14e940eed094b5e9ffde41b5a4398fbf type Axiom @default.
- B14e940eed094b5e9ffde41b5a4398fbf annotatedProperty IAO_0000115 @default.
- B14e940eed094b5e9ffde41b5a4398fbf annotatedSource NCIT_C92574 @default.
- B14e940eed094b5e9ffde41b5a4398fbf annotatedTarget "A small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity. Apalutamide binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes. This ultimately inhibits the expression of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells." @default.