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- B14eaa8bbea31de461077c850764f1d41 NCIT_P378 "NCI" @default.
- B14eaa8bbea31de461077c850764f1d41 type Axiom @default.
- B14eaa8bbea31de461077c850764f1d41 annotatedProperty IAO_0000115 @default.
- B14eaa8bbea31de461077c850764f1d41 annotatedSource NCIT_C121538 @default.
- B14eaa8bbea31de461077c850764f1d41 annotatedTarget "A human immunoglobulin (Ig) G1 monoclonal antibody directed against the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration, mitazalimab binds to CD40 on antigen-presenting dendritic cells, which leads to the activation and proliferation of effector and memory T-cells, and enhances the immune response against tumor cells. In addition, this agent binds to the CD40 antigen present on the surfaces of tumor cells, which induces antibody-dependent cytotoxicity (ADCC). This eventually inhibits the proliferation of CD40-expressing tumor cells. CD40, a stimulatory receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells, such as macrophages, dendritic cells and various tumor cell types; it plays a key role in the activation of the immune system." @default.