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- B1592792d7152661932c034deb8c1ef0f NCIT_P378 "NCI" @default.
- B1592792d7152661932c034deb8c1ef0f type Axiom @default.
- B1592792d7152661932c034deb8c1ef0f annotatedProperty IAO_0000115 @default.
- B1592792d7152661932c034deb8c1ef0f annotatedSource NCIT_C103277 @default.
- B1592792d7152661932c034deb8c1ef0f annotatedTarget "An inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. Acalisib inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells." @default.