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- B15a7ddb156f475dbba4d42143a954682 NCIT_P378 "NCI" @default.
- B15a7ddb156f475dbba4d42143a954682 type Axiom @default.
- B15a7ddb156f475dbba4d42143a954682 annotatedProperty IAO_0000115 @default.
- B15a7ddb156f475dbba4d42143a954682 annotatedSource NCIT_C62021 @default.
- B15a7ddb156f475dbba4d42143a954682 annotatedTarget "A semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.