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- B15f8a940bcc893e95b6adf3d223b814b NCIT_P378 "NCI" @default.
- B15f8a940bcc893e95b6adf3d223b814b type Axiom @default.
- B15f8a940bcc893e95b6adf3d223b814b annotatedProperty IAO_0000115 @default.
- B15f8a940bcc893e95b6adf3d223b814b annotatedSource NCIT_C49185 @default.
- B15f8a940bcc893e95b6adf3d223b814b annotatedTarget "Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue." @default.