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- B16138873fe424de2da98d0dc741dd68d NCIT_P378 "NCI" @default.
- B16138873fe424de2da98d0dc741dd68d type Axiom @default.
- B16138873fe424de2da98d0dc741dd68d annotatedProperty IAO_0000115 @default.
- B16138873fe424de2da98d0dc741dd68d annotatedSource NCIT_C62040 @default.
- B16138873fe424de2da98d0dc741dd68d annotatedTarget "A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent." @default.