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- B166e6f14f2d9013bf7e37661d3b52b2f NCIT_P378 "NCI" @default.
- B166e6f14f2d9013bf7e37661d3b52b2f type Axiom @default.
- B166e6f14f2d9013bf7e37661d3b52b2f annotatedProperty IAO_0000115 @default.
- B166e6f14f2d9013bf7e37661d3b52b2f annotatedSource NCIT_C101132 @default.
- B166e6f14f2d9013bf7e37661d3b52b2f annotatedTarget "An active metabolite of NV-128, a novel flavonoid small molecule inhibitor of the mammalian Target of Rapamycin (mTOR), with potential antineoplastic activity. Upon administration, mTOR1/2 Kinase inhibitor ME-344 downregulates the PIK3/AKT/mTOR pathway and results in chromatin condensation in the absence of caspase activation. Consequently, this agent induces caspase-independent cell death in tumor cells with a de-regulated PIK3/AKT/mTOR pathway or chemotherapeutic resistant cells." @default.