Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B169518ffc53fcb2bdfc9d9729ae847c8> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B169518ffc53fcb2bdfc9d9729ae847c8 NCIT_P378 "NCI" @default.
- B169518ffc53fcb2bdfc9d9729ae847c8 type Axiom @default.
- B169518ffc53fcb2bdfc9d9729ae847c8 annotatedProperty IAO_0000115 @default.
- B169518ffc53fcb2bdfc9d9729ae847c8 annotatedSource NCIT_C162883 @default.
- B169518ffc53fcb2bdfc9d9729ae847c8 annotatedTarget "An injectable peptide mimetic of hepcidin (hepcidin antimicrobial peptide; HAMP; putative liver tumor regressor; PLTR; liver-expressed antimicrobial peptide 1; LEAP-1) with potential use in the treatment of iron deficiency anemia and iron overload secondary to hematologic disorders. Upon administration, rusfertide mimics endogenous hepcidin, a protein primarily produced in hepatocytes, and increases hepcidin levels. As hepcidin plays a key role in the homeostasis of systemic iron, rusfertide may serve to normalize iron levels. Low levels of endogenous hepcidin are associated with iron overload secondary to excessive absorption of iron as seen in beta thalassemia and paradoxically with iron deficiency anemia." @default.