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- B1703c42601a6d68c69fae3274f580138 NCIT_P378 "NCI" @default.
- B1703c42601a6d68c69fae3274f580138 type Axiom @default.
- B1703c42601a6d68c69fae3274f580138 annotatedProperty IAO_0000115 @default.
- B1703c42601a6d68c69fae3274f580138 annotatedSource NCIT_C47506 @default.
- B1703c42601a6d68c69fae3274f580138 annotatedTarget "An imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties. Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components. In addition, econazole nitrate inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative enzyme activity which may contribute to cellular necrosis and cell death. Econazole nitrate is also active against some gram positive bacteria. This antifungal agent is used in the treatment various dermatomycoses." @default.