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- B174a864d4024d3f3996b845790aaa32c NCIT_P378 "NCI" @default.
- B174a864d4024d3f3996b845790aaa32c type Axiom @default.
- B174a864d4024d3f3996b845790aaa32c annotatedProperty IAO_0000115 @default.
- B174a864d4024d3f3996b845790aaa32c annotatedSource NCIT_C98293 @default.
- B174a864d4024d3f3996b845790aaa32c annotatedTarget "A fully human IgG1 monoclonal antibody directed against the cell surface glycoprotein mesothelin and conjugated to the maytansinoid DM4 with potential antineoplastic activity. The monoclonal antibody moiety of anetumab ravtansine targets and binds to the tumor associated antigen mesothelin; upon internalization, the DM4 moiety binds to tubulin and disrupts microtubule assembly/disassembly dynamics, resulting in inhibition of cell division and cell growth of mesothelin-expressing tumor cells. Mesothelin is overexpressed on all mesotheliomas as well as many ovarian and pancreatic cancers while minimally expressed on normal tissue." @default.