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- B17d525c372a19f1b3852023ea9f49ae1 NCIT_P378 "NCI" @default.
- B17d525c372a19f1b3852023ea9f49ae1 type Axiom @default.
- B17d525c372a19f1b3852023ea9f49ae1 annotatedProperty IAO_0000115 @default.
- B17d525c372a19f1b3852023ea9f49ae1 annotatedSource NCIT_C95224 @default.
- B17d525c372a19f1b3852023ea9f49ae1 annotatedTarget "The difumarate salt of saracatinib, an orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption." @default.