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- B180db917b4a6bc329c85a80f79a6cb52 NCIT_P378 "NCI" @default.
- B180db917b4a6bc329c85a80f79a6cb52 type Axiom @default.
- B180db917b4a6bc329c85a80f79a6cb52 annotatedProperty IAO_0000115 @default.
- B180db917b4a6bc329c85a80f79a6cb52 annotatedSource NCIT_C37454 @default.
- B180db917b4a6bc329c85a80f79a6cb52 annotatedTarget "A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics." @default.