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- B187d72d5396e63927e339213c4733170 NCIT_P378 "NCI" @default.
- B187d72d5396e63927e339213c4733170 type Axiom @default.
- B187d72d5396e63927e339213c4733170 annotatedProperty IAO_0000115 @default.
- B187d72d5396e63927e339213c4733170 annotatedSource NCIT_C189093 @default.
- B187d72d5396e63927e339213c4733170 annotatedTarget "A preparation of tumor-infiltrating lymphocytes (TILs) that have been genetically engineered to express membrane-bound IL-15 (mbIL15), with potential immunostimulating and antineoplastic activities. Upon introduction of the mbIL15-expressing TILs OBX-115, the TILs target and kill tumor cells. IL-15 is a pro-survival cytokine that is required for the maintenance of long-lived CD8+ memory T-cells. Sustained IL-15 signaling enhances TIL persistence and potency compared to un-engineered TILs. OBX-115 may replace the need for concomitant administration of systemic IL-2 which is needed to improve the efficacy of conventional TILs." @default.