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- B188d8bc6ff48955aba9c3871377a720c NCIT_P378 "NCI" @default.
- B188d8bc6ff48955aba9c3871377a720c type Axiom @default.
- B188d8bc6ff48955aba9c3871377a720c annotatedProperty IAO_0000115 @default.
- B188d8bc6ff48955aba9c3871377a720c annotatedSource NCIT_C1311 @default.
- B188d8bc6ff48955aba9c3871377a720c annotatedTarget "A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent." @default.