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- B18f90e900033558a973bea320a9dc96e NCIT_P378 "NCI" @default.
- B18f90e900033558a973bea320a9dc96e type Axiom @default.
- B18f90e900033558a973bea320a9dc96e annotatedProperty IAO_0000115 @default.
- B18f90e900033558a973bea320a9dc96e annotatedSource NCIT_C188312 @default.
- B18f90e900033558a973bea320a9dc96e annotatedTarget "A bispecific antibody directed against both the tumor-associated antigen (TAA) CD19 and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/CD28 bispecific antibody RO7443904 targets and binds to both CD28 expressed on T-cells and CD19 expressed on tumor cells, which crosslinks the T-cells to the tumor cells. This may result in a potent cytotoxic T-lymphocyte (CTL) response against the CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies." @default.