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- B192a33aa6ae352a5ec4e537e8ac78a61 NCIT_P378 "BIOCARTA" @default.
- B192a33aa6ae352a5ec4e537e8ac78a61 type Axiom @default.
- B192a33aa6ae352a5ec4e537e8ac78a61 annotatedProperty NCIT_P325 @default.
- B192a33aa6ae352a5ec4e537e8ac78a61 annotatedSource NCIT_C39059 @default.
- B192a33aa6ae352a5ec4e537e8ac78a61 annotatedTarget "Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis. Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway. The EGF receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT. The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF. (This definition may be outdated - see the DesignNote.)" @default.