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- B192baa8415dc647d3fa347a44bdbf022 NCIT_P378 "NCI" @default.
- B192baa8415dc647d3fa347a44bdbf022 type Axiom @default.
- B192baa8415dc647d3fa347a44bdbf022 annotatedProperty IAO_0000115 @default.
- B192baa8415dc647d3fa347a44bdbf022 annotatedSource NCIT_C95710 @default.
- B192baa8415dc647d3fa347a44bdbf022 annotatedTarget "An antibody-drug conjugate (ADC) containing labetuzumab, a mildly reduced, anti-CEACAM5 humanized monoclonal antibody, conjugated to the potent topoisomerase I inhibitor SN-38, with antineoplastic activity. The monoclonal antibody moiety of labetuzumab govitecan selectively binds to carcinoembryonic cell adhesion molecule 5 (CEACAM5), which is abundantly expressed on the surface of a majority of solid tumors. Upon internalization and proteolytic cleavage, SN-38, the active metabolite of irinotecan, inhibits the activity of topoisomerase I in the tumor cells, eventually inhibiting both DNA replication and transcription and leading to tumor cell apoptosis." @default.