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- B1947cdfd27dc5e720d7c8dd3ec824d7a NCIT_P378 "NCI" @default.
- B1947cdfd27dc5e720d7c8dd3ec824d7a type Axiom @default.
- B1947cdfd27dc5e720d7c8dd3ec824d7a annotatedProperty IAO_0000115 @default.
- B1947cdfd27dc5e720d7c8dd3ec824d7a annotatedSource NCIT_C358 @default.
- B1947cdfd27dc5e720d7c8dd3ec824d7a annotatedTarget "The sodium salt form of cephalothin, a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.