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- B19a3f2d226d1536b7bcb1bb01f5db2c3 NCIT_P378 "NCI" @default.
- B19a3f2d226d1536b7bcb1bb01f5db2c3 type Axiom @default.
- B19a3f2d226d1536b7bcb1bb01f5db2c3 annotatedProperty IAO_0000115 @default.
- B19a3f2d226d1536b7bcb1bb01f5db2c3 annotatedSource NCIT_C1177 @default.
- B19a3f2d226d1536b7bcb1bb01f5db2c3 annotatedTarget "A synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types." @default.