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- B19bf94d46da2f8d1d41609f17fa346c7 NCIT_P378 "NCI" @default.
- B19bf94d46da2f8d1d41609f17fa346c7 type Axiom @default.
- B19bf94d46da2f8d1d41609f17fa346c7 annotatedProperty IAO_0000115 @default.
- B19bf94d46da2f8d1d41609f17fa346c7 annotatedSource NCIT_C48186 @default.
- B19bf94d46da2f8d1d41609f17fa346c7 annotatedTarget "This process is initiated by the formation of heterochromatin which ultimately leads to transcriptional inactivation or silencing. Once formed, heterochromatin can be inherited through many cell divisions, including meiosis. Inappropriate gain of heterochromatin structure, such as the inactivation of tumor suppressor genes by DNA hyper-methylation at their promoter regions, can be directly linked to carcinogenesis." @default.