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- B1a428a690d38d24b5173c77d700903a8 NCIT_P378 "NCI" @default.
- B1a428a690d38d24b5173c77d700903a8 type Axiom @default.
- B1a428a690d38d24b5173c77d700903a8 annotatedProperty IAO_0000115 @default.
- B1a428a690d38d24b5173c77d700903a8 annotatedSource NCIT_C21292 @default.
- B1a428a690d38d24b5173c77d700903a8 annotatedTarget "Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptor Genes encode Beta Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI)" @default.