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- B1ab0d988ab707fb5a033bc841567014f NCIT_P378 "NCI" @default.
- B1ab0d988ab707fb5a033bc841567014f type Axiom @default.
- B1ab0d988ab707fb5a033bc841567014f annotatedProperty IAO_0000115 @default.
- B1ab0d988ab707fb5a033bc841567014f annotatedSource NCIT_C1010 @default.
- B1ab0d988ab707fb5a033bc841567014f annotatedTarget "A pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of prostacyclin (prostaglandin I2; PGI2) and prevents intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. An elevated level of PGI2 prevents aggregation of platelets; subsequently it decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis." @default.