Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B1ab106b9ff5d867da9c4ffc16ba80fd9> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B1ab106b9ff5d867da9c4ffc16ba80fd9 NCIT_P378 "NCI" @default.
- B1ab106b9ff5d867da9c4ffc16ba80fd9 type Axiom @default.
- B1ab106b9ff5d867da9c4ffc16ba80fd9 annotatedProperty IAO_0000115 @default.
- B1ab106b9ff5d867da9c4ffc16ba80fd9 annotatedSource NCIT_C133691 @default.
- B1ab106b9ff5d867da9c4ffc16ba80fd9 annotatedTarget "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, aumolertinib binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.