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- B1ab780c19878e6a9733263e890e5778e NCIT_P378 "NCI" @default.
- B1ab780c19878e6a9733263e890e5778e type Axiom @default.
- B1ab780c19878e6a9733263e890e5778e annotatedProperty IAO_0000115 @default.
- B1ab780c19878e6a9733263e890e5778e annotatedSource NCIT_C84511 @default.
- B1ab780c19878e6a9733263e890e5778e annotatedTarget "The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a "telomerase template antagonist"), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis." @default.