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- B1b6a8f003300154b9e3902d2e5917bca NCIT_P378 "NCI" @default.
- B1b6a8f003300154b9e3902d2e5917bca type Axiom @default.
- B1b6a8f003300154b9e3902d2e5917bca annotatedProperty IAO_0000115 @default.
- B1b6a8f003300154b9e3902d2e5917bca annotatedSource NCIT_C519 @default.
- B1b6a8f003300154b9e3902d2e5917bca annotatedTarget "A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses." @default.