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- B1b868518629b538001e229ef86ce3b66 NCIT_P378 "NCI" @default.
- B1b868518629b538001e229ef86ce3b66 type Axiom @default.
- B1b868518629b538001e229ef86ce3b66 annotatedProperty IAO_0000115 @default.
- B1b868518629b538001e229ef86ce3b66 annotatedSource NCIT_C49181 @default.
- B1b868518629b538001e229ef86ce3b66 annotatedTarget "An orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies." @default.