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- B1b92b5f54e42e48e4cd333fdd517db24 NCIT_P378 "NCI" @default.
- B1b92b5f54e42e48e4cd333fdd517db24 type Axiom @default.
- B1b92b5f54e42e48e4cd333fdd517db24 annotatedProperty IAO_0000115 @default.
- B1b92b5f54e42e48e4cd333fdd517db24 annotatedSource NCIT_C394 @default.
- B1b92b5f54e42e48e4cd333fdd517db24 annotatedTarget "Any synthetic therapeutic agent which is chemically identical to or similar to the endogenous human corticotropin-releasing factor (hCRF). Synthesized in the hypothalamus, hCRF stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH). In cerebral edema, hCRF acts by impeding the flow of fluid from blood vessels into brain tissue, thereby decreasing edema and stabilizing intracranial pressure. This agent possesses anti-edema properties independent of adrenal gland function. (NCI05)" @default.