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- B1bd5f8acf2c07e19d0e80404f27603b7 NCIT_P378 "NCI" @default.
- B1bd5f8acf2c07e19d0e80404f27603b7 type Axiom @default.
- B1bd5f8acf2c07e19d0e80404f27603b7 annotatedProperty IAO_0000115 @default.
- B1bd5f8acf2c07e19d0e80404f27603b7 annotatedSource NCIT_C652 @default.
- B1bd5f8acf2c07e19d0e80404f27603b7 annotatedTarget "The hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system." @default.