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- B1c03f7a717db75c01ab26e6fa096d517 NCIT_P378 "NCI" @default.
- B1c03f7a717db75c01ab26e6fa096d517 type Axiom @default.
- B1c03f7a717db75c01ab26e6fa096d517 annotatedProperty IAO_0000115 @default.
- B1c03f7a717db75c01ab26e6fa096d517 annotatedSource NCIT_C171629 @default.
- B1c03f7a717db75c01ab26e6fa096d517 annotatedTarget "A complex between the enzyme DNA topoisomerase 1 (TOP1) and its DNA substrate. Under normal conditions these complexes are transient and found at low levels. In the presence of therapeutic TOP1 inhibitors these complexes are stabilized, which prevents DNA religation and induces lethal DNA strand breaks." @default.