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- B1c1b6a48f3fdbf6311e9c65f703a66a3 NCIT_P378 "NCI" @default.
- B1c1b6a48f3fdbf6311e9c65f703a66a3 type Axiom @default.
- B1c1b6a48f3fdbf6311e9c65f703a66a3 annotatedProperty IAO_0000115 @default.
- B1c1b6a48f3fdbf6311e9c65f703a66a3 annotatedSource NCIT_C162480 @default.
- B1c1b6a48f3fdbf6311e9c65f703a66a3 annotatedTarget "An orally available inhibitor of methionine aminopeptidase II type (MetAP2) with potential antiangiogenic and antineoplastic activities. Upon administration, APL-1202 binds to and reversibly inhibits MetAP2, thereby preventing MetAP2-mediated signal transduction pathways. This may suppress endothelial cell growth and inhibit tumor angiogenesis, resulting in tumor cell death. MetAP2, a member of the dimetallohydrolase family, is upregulated in certain tumor cell types and plays a key role in angiogenesis, proliferation and survival." @default.