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- B1c39a54e23671cee2e3deb9d2a22190f NCIT_P378 "NCI" @default.
- B1c39a54e23671cee2e3deb9d2a22190f type Axiom @default.
- B1c39a54e23671cee2e3deb9d2a22190f annotatedProperty IAO_0000115 @default.
- B1c39a54e23671cee2e3deb9d2a22190f annotatedSource NCIT_C62072 @default.
- B1c39a54e23671cee2e3deb9d2a22190f annotatedTarget "A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction." @default.