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- B1c66d8d68c08a8bca80ca575f6253f1c NCIT_P378 "NCI" @default.
- B1c66d8d68c08a8bca80ca575f6253f1c type Axiom @default.
- B1c66d8d68c08a8bca80ca575f6253f1c annotatedProperty IAO_0000115 @default.
- B1c66d8d68c08a8bca80ca575f6253f1c annotatedSource NCIT_C156772 @default.
- B1c66d8d68c08a8bca80ca575f6253f1c annotatedTarget "A radioconjugate containing LLP2A, a high-affinity peptidomimetic ligand for the tumor-associated antigen (TAA) very-late-antigen-4 (VLA-4; VLA 4; alpha4beta1 integrin; CD49d/CD29), conjugated, via the chelator 1,4,8,11-tetraazacyclotetradecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) (CB-TE1A1P), to the radioisotope copper Cu 64, and conjugated to polyethylene glycol (PEG) chains that can potentially be used as a diagnostic imaging agent of VLA-4-expressing tumor cells using positron-emitting tomography (PET). Upon administration, copper Cu 64-CB-TE1A1P-PEG4-LLP2A targets, binds to and is taken up by VLA-4-expressing tumor cells. Upon PET, the VLA-4-expressing tumor cells can be visualized, and the tumor can be assessed. VLA-4, a transmembrane adhesion receptor overexpressed and activated on various tumor cell types and surrounding stroma, plays an important role in tumor growth, angiogenesis, metastasis, drug resistance and immune responses. Pegylation optimizes the pharmacokinetic profile of 64Cu-LLP2A." @default.