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- B1c76bf518c543e6d762597bb415fd432 NCIT_P378 "NCI" @default.
- B1c76bf518c543e6d762597bb415fd432 type Axiom @default.
- B1c76bf518c543e6d762597bb415fd432 annotatedProperty IAO_0000115 @default.
- B1c76bf518c543e6d762597bb415fd432 annotatedSource NCIT_C406 @default.
- B1c76bf518c543e6d762597bb415fd432 annotatedTarget "A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)" @default.