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- B1c8d6826b75ef68f4c82e0f752142805 NCIT_P378 "NCI" @default.
- B1c8d6826b75ef68f4c82e0f752142805 type Axiom @default.
- B1c8d6826b75ef68f4c82e0f752142805 annotatedProperty IAO_0000115 @default.
- B1c8d6826b75ef68f4c82e0f752142805 annotatedSource NCIT_C85444 @default.
- B1c8d6826b75ef68f4c82e0f752142805 annotatedTarget "An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis." @default.