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- B1d8c021d469b4b00b554d83c4dd0f6d2 NCIT_P378 "NCI" @default.
- B1d8c021d469b4b00b554d83c4dd0f6d2 type Axiom @default.
- B1d8c021d469b4b00b554d83c4dd0f6d2 annotatedProperty IAO_0000115 @default.
- B1d8c021d469b4b00b554d83c4dd0f6d2 annotatedSource NCIT_C850 @default.
- B1d8c021d469b4b00b554d83c4dd0f6d2 annotatedTarget "A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. (NCI04)" @default.