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- B1dac7062d41ca0b80650219ee363b60c NCIT_P378 "NCI" @default.
- B1dac7062d41ca0b80650219ee363b60c type Axiom @default.
- B1dac7062d41ca0b80650219ee363b60c annotatedProperty IAO_0000115 @default.
- B1dac7062d41ca0b80650219ee363b60c annotatedSource NCIT_C239 @default.
- B1dac7062d41ca0b80650219ee363b60c annotatedTarget "A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections." @default.